Thaggede Le story is about a murder investigation that revolves around nabbing of a drug lord. SI Chalapathy (Ravi Shankar) and his subordinate Raja (Raja Raveendra) bring Easwar (Naveen Chandra) , a software engineer to a Daba and start interrogating him over a murder case. Even as they are busy with their interrogation, the drug mafia is furious with the missing cartel and the dreaded Dandupalyam gang comprising gang leader Krishna (Makarand Desh Pande), Lakshmi (Pooja Gandhi), Chander (Ravi Kale), and others escape. Where this leads to and what is the connection to the murder mystery and how they are related to Eswar's wife Devi (Divya Pillai), Lizy (Ananaya SenGupta) form the crux of Thaggede Le.

Two college students, Arjun and Akshara, get off on the wrong foot and develop an instant hatred for each other. However, they land in a pickle and realise their connection from a past life.

Defeated and humiliated in a fight while trying to defuse a conflict among his fellow villagers, a photographer vows revenge on his attacker.

Nani plays the gang leader of five women belonging to different age groups, helping them to plot revenge.